Understanding how a specific gene affects smooth muscle cells in blood vessels
PIK3C3, a master regulator for smooth muscle identity
This study is looking at how a specific gene called PIK3C3 affects the health of blood vessels, which is important for people with heart conditions, by using special mice to see what happens when this gene is changed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-10991015 on NIH RePORTER |
What this research studies
This research investigates the role of the PIK3C3 gene in vascular smooth muscle cells (VSMCs), which are crucial for maintaining the health of blood vessels. By analyzing data from human atherosclerotic plaques and coronary artery disease, the researchers aim to uncover how changes in this gene can lead to vascular diseases. The study involves creating genetically modified mice to observe the effects of PIK3C3 deletion on vascular health and disease progression. This approach may reveal important insights into the mechanisms behind vascular diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of atherosclerotic cardiovascular disease or related vascular conditions.
Not a fit: Patients without any vascular diseases or those with non-atherosclerotic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for atherosclerotic cardiovascular diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown that targeting similar pathways in vascular smooth muscle cells can lead to significant advancements in understanding and treating vascular diseases.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Zhou, Jiliang — Augusta University
- Study coordinator: Zhou, Jiliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.