Understanding how a specific gene affects immune system function
Unraveling the Molecular Function of Mosaic, a gene mediating immune dysregulation
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10653017
This study is looking at how the Mosaic gene helps control the immune system, which is important for keeping our bodies balanced and fighting off tumors, and it's for people with autoimmune diseases or adrenal disorders who might benefit from new treatments.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10653017 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Mosaic gene in immune regulation, which is crucial for maintaining tolerance and monitoring tumors. By studying both animal models and patients with immune dysregulation disorders, the research aims to uncover the biological mechanisms that lead to immune-related conditions. The findings could potentially translate into new clinical therapies to improve patient care for those affected by autoimmune diseases and adrenal disorders. The project is led by Dr. Alice Chan, who has extensive experience in pediatric rheumatology and allergy/immunology.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with autoimmune diseases, adrenal disorders, or those experiencing immune dysregulation.
Not a fit: Patients with non-autoimmune conditions or those not affected by immune dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve treatment options for patients with immune dysregulation and related conditions.
How similar studies have performed: Previous research has shown success in understanding immune regulation through similar approaches, indicating a promising avenue for further exploration.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAN, ALICE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: CHAN, ALICE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Addison's disease, Adrenal Gland Disorder, adrenal disorder, Adrenal Gland Diseases, Autoimmune Diseases