Understanding how a specific enzyme from Staphylococcus aureus affects the immune response.
Official title: Elucidating the Role of a Staphylococcus aureus Glucosaminidase in the Innate Immune Response.
Funded at University of Illinois at Chicago · NIH-10994827 · Data updated 2026-11-12
This study is looking at how a specific enzyme from the Staphylococcus aureus bacteria affects our immune system's response to infections, with the hope that understanding this could help develop better treatments for people dealing with these infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $46,377 |
| NIH project number | 1F31AI186287-01 |
| Project ID | NIH-10994827 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with infections caused by Staphylococcus aureus, especially those experiencing complications due to antibiotic resistance.
✕Less likely to help
Patients with infections caused by other pathogens or those who do not have Staphylococcus aureus infections may not benefit from this research.
What this research studies
This research investigates the role of a glucosaminidase enzyme produced by Staphylococcus aureus in the body's innate immune response. By examining how this enzyme interacts with the bacterial cell wall, the study aims to uncover mechanisms that influence inflammation and infection outcomes. The research involves analyzing immune cell responses to the bacterial components and how these interactions can lead to either effective infection clearance or prolonged inflammation. Patients may benefit from insights gained that could lead to improved treatments for infections caused by this pathogen.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by Staphylococcus aureus, particularly in overcoming antibiotic resistance.
How similar studies have gone: Previous research has shown promising results in understanding immune responses to bacterial components, indicating that this approach has potential for success.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Johnson, Kaelie Renee — University of Illinois at Chicago
- Study coordinator: Johnson, Kaelie Renee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.