Understanding how a specific cytokine affects immune cells in rheumatoid arthritis
Identifying a novel pathway that regulates RA immunometabolism
This study is looking at how a certain protein affects immune cells in people with rheumatoid arthritis, hoping to find new ways to help improve treatments for the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10662549 on NIH RePORTER |
What this research studies
This research investigates the role of a specific cytokine in the transformation of immune cells in patients with rheumatoid arthritis (RA). It focuses on how this cytokine influences the metabolism of monocytes, leading them to become inflammatory macrophages that contribute to joint damage. By exploring the molecular mechanisms involved, the study aims to identify new therapeutic strategies that could improve treatment responses for RA patients. The research involves laboratory experiments to analyze cell behavior and metabolic changes in response to the cytokine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who may be experiencing inadequate responses to current therapies.
Not a fit: Patients with rheumatoid arthritis who are already responding well to existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better control inflammation and joint damage in rheumatoid arthritis patients.
How similar studies have performed: Other research has shown promising results in targeting immune cell metabolism in autoimmune diseases, suggesting potential for success in this novel approach.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Shahrara, Shiva — University of Illinois at Chicago
- Study coordinator: Shahrara, Shiva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.