Understanding how a specific circular RNA affects immune cells involved in autoimmune diseases
Determining the mechanisms by which a circular RNA regulates the function of Th17 cells
This study is looking at a special type of RNA called circUsp3 to see how it affects a kind of immune cell that plays a big role in autoimmune diseases, with the hope of finding new ways to help people who are dealing with these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10814585 on NIH RePORTER |
What this research studies
This research investigates the role of a circular RNA called circUsp3 in regulating Th17 cells, which are crucial in the development of autoimmune diseases. By exploring how circUsp3 influences the differentiation and function of these immune cells, the research aims to uncover new therapeutic targets for treating autoimmune conditions. The approach includes both in vitro experiments to study cell behavior and in vivo models to observe effects in living organisms. The ultimate goal is to provide insights that could lead to innovative treatments for patients suffering from autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases, particularly those characterized by Th17 cell involvement.
Not a fit: Patients with autoimmune diseases not related to Th17 cell activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically inhibit harmful immune responses in autoimmune diseases.
How similar studies have performed: While the role of circular RNAs in immune function is an emerging field, this specific investigation into circUsp3 and Th17 cells is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: He, Zhiheng — University of Southern California
- Study coordinator: He, Zhiheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.