Understanding how a special protein pathway helps brain connections work in conditions like autism
Linking an activity-dependent BMP pathway to synapse structure and function
This work explores how a specific protein pathway, called BMP, helps organize brain connections, which could offer new insights into brain disorders like autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11060017 on NIH RePORTER |
What this research studies
Our brains rely on tiny connections called synapses to function properly, and problems with these connections are linked to conditions like autism. This project looks at how a natural signaling pathway, the Bone Morphogenetic Protein (BMP) pathway, helps build and maintain these crucial brain connections. We are discovering how this pathway works at a very detailed level, including how it helps keep brain cells properly attached and aligned. By understanding these fundamental processes, we hope to uncover new ways to think about and address brain disorders.
Who could benefit from this research
Good fit: This foundational work is relevant to individuals with brain disorders, particularly those with autistic disorder, as it seeks to understand underlying biological mechanisms.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this basic understanding of brain connections could lead to new targets for therapies for brain disorders, including autistic disorder.
How similar studies have performed: This project builds on novel findings from the research team, exploring innovative hypotheses about how growth factors organize synapses.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Broihier, Heather — Case Western Reserve University
- Study coordinator: Broihier, Heather
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.