Understanding how a protein spreads from the gut to the brain in Parkinson's disease
Towards a comprehensive understanding of the neurotoxic spread of α-synuclein from gut to brain in Parkinson's disease
This study is looking at how a protein linked to Parkinson's disease moves from the gut to the brain, using tiny worms to help find new ways to understand and potentially treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-10910663 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which α-synuclein, a protein associated with Parkinson's disease, spreads from the gastrointestinal tract to the brain. Using the model organism C. elegans, the study aims to create new models that can help identify how this protein aggregation leads to neurodegeneration and behavioral changes. By mapping the spread of α-synuclein and examining different neuronal cell types, the research seeks to uncover the underlying processes that contribute to the disease. This approach allows for high-throughput screening to accelerate the discovery of potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk due to familial history or early symptoms.
Not a fit: Patients with Parkinson's disease who are already in advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for Parkinson's disease, improving outcomes for patients.
How similar studies have performed: Other research has shown success in using model organisms like C. elegans to study neurodegenerative diseases, indicating that this approach has potential.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Mor, Danielle Emille — Augusta University
- Study coordinator: Mor, Danielle Emille
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.