Understanding how a protein regulates eye infections caused by bacteria.
A novel regulator of Pseudomonas aeruginosa keratitis
This study is looking at how a protein called CDCP1 helps the eye fight off infections from a common bacteria, aiming to find new ways to treat eye infections for people who may be affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10618396 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called CDCP1 in the immune response of the eye, particularly in relation to infections caused by the bacteria Pseudomonas aeruginosa. By using various models, including human and mouse corneal cells, the researchers aim to uncover how CDCP1 helps control bacterial infections and maintain eye health. The study will explore both the intrinsic functions of CDCP1 in corneal cells and its interactions with immune cells, specifically γδ T cells. The ultimate goal is to develop new therapeutic strategies targeting CDCP1 to better manage bacterial keratitis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from bacterial keratitis or those at risk of developing eye infections.
Not a fit: Patients with non-bacterial eye conditions or those not affected by corneal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bacterial eye infections, improving outcomes for patients with keratitis.
How similar studies have performed: Previous research has shown promising results in targeting immune regulators for treating infections, suggesting potential success for this novel approach.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Lin, Feng C — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Lin, Feng C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.