Understanding how a protein complex affects kidney cell changes
Official title: The role of the COP9 signalosome in distal nephron remodeling
Funded at Oregon Health & Science University · NIH-10723624 · Data updated 2026-11-12
This study is looking at how certain kidney cells change and adapt when influenced by diet and diseases, which could help us find better ways to treat kidney problems.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $231,000 |
| NIH project number | 1R03DK137034-01 |
| Project ID | NIH-10723624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with kidney disorders such as familial hyperkalemic hypertension or those experiencing diuretic resistance.
✕Less likely to help
Patients with unrelated kidney conditions or those not experiencing any renal dysfunction may not benefit from this research.
What this research studies
This research investigates the role of the COP9 signalosome in the remodeling of distal nephron cells in the kidneys, which is important for understanding various kidney-related diseases. The study will utilize advanced techniques like single-cell transcriptomics to analyze how dietary factors and certain diseases influence the behavior of kidney cells. By examining the cellular and molecular mechanisms involved, the research aims to uncover how these cells adapt and change in response to different conditions, which could lead to better treatment strategies for kidney disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for kidney diseases and conditions related to blood pressure regulation.
How similar studies have gone: Previous research has shown promising results in understanding kidney cell behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Cornelius, Ryan J — Oregon Health & Science University
- Study coordinator: Cornelius, Ryan J
Related research
Other NIH-funded projects on the same topics.
-
Understanding how a protein affects nerve cell movement in Alzheimer's disease
This study is looking at how a protein called APP affects the growth and movement of nerve cells, which is important for understanding Alzheimer's disease, and it aims to find out how problems with this protein might lead to nerve cell damage.
-
Understanding how the bone marrow environment drives AML resistance
A large NIH-funded project at Oregon Health & Science University is studying how the body’s own cell surroundings help acute myeloid leukemia become resistant to treatment, with potential paths to better therapies for patients.
-
Improving Safety at Work with a Low-Resource mHealth Program in Malaysia (and beyond)
A low-cost mobile health program to improve safety culture in Malaysian workplaces, with plans to adapt the approach for U.S. workers in high-risk industries.
-
Oregon Healthy Workplace Initiative for Better Health
A multi-site effort aims to improve the health and safety of workers by coordinating research, tools, and interventions across workplaces.
-
Understanding how AML cells become resistant to therapy over time
This project looks at why acute myeloid leukemia stops responding to treatment and how to design better drug combinations to prevent relapse.
-
Mechanisms and Countermeasures for Ultra-Potent Synthetic Opioid Overdose
A small, focused NIH grant aims to understand why ultra-potent synthetic opioids cause severe overdose and to explore potential countermeasures to keep people safe.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.