Understanding how a protein complex affects brain function
Official title: Probing the Role of Integrator in Neuronal Function
Funded at University of Rochester · NIH-10932229 · Data updated 2026-11-12
This study is looking at a group of proteins that help control how genes work in brain cells, and it's for anyone interested in understanding how these proteins might affect brain development and conditions like neurological disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 20, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $627,436 |
| NIH project number | 5R01NS135070-02 |
| Project ID | NIH-10932229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic variants affecting the Integrator Complex or related proteins, particularly those experiencing neurological symptoms.
✕Less likely to help
Patients with neurological conditions unrelated to the Integrator Complex or its associated proteins may not benefit from this research.
What this research studies
This research investigates the Integrator Complex, a group of proteins that play a crucial role in regulating gene expression in neurons. By examining how these proteins interact and function, the study aims to uncover their impact on brain development and disorders. The researchers will use advanced techniques like cryo-electron microscopy to visualize these protein interactions and understand their significance in neuronal health. This work could provide insights into the mechanisms behind certain neurological conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating brain disorders linked to Integrator dysfunction.
How similar studies have gone: While the specific role of the Integrator Complex in neuronal function is still being explored, similar research has shown promise in understanding the genetic basis of neurological disorders.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Wagner, Eric J — University of Rochester
- Study coordinator: Wagner, Eric J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.