Understanding how a protein complex affects brain cell development
Official title: Characterization of the Integrator-Z3 module as a regulator of neuronal differentiation
Funded at University of Rochester · NIH-10995745 · Data updated 2026-11-12
This study is looking at how a specific protein complex helps brain cells develop properly, which could help us understand why some people have brain disorders like cerebellar ataxia.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31NS139499-01 |
| Project ID | NIH-10995745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting neuronal function, particularly those experiencing symptoms like cerebellar ataxia or intellectual disabilities.
✕Less likely to help
Patients with neurological disorders not linked to the Integrator-Z3 module or those without identifiable genetic mutations may not benefit from this research.
What this research studies
This research investigates the role of the Integrator-Z3 module in the differentiation of neurons, which are crucial for brain function. By examining how this protein complex interacts with DNA and influences gene expression, the study aims to uncover the underlying mechanisms that lead to neurological disorders. The approach includes biochemical techniques and RNA sequencing to analyze changes in gene activity when specific proteins are altered. This could provide insights into how disruptions in these processes contribute to conditions like cerebellar ataxia and other brain disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders linked to neuronal differentiation.
How similar studies have gone: Previous research has shown that understanding protein complexes involved in gene regulation can lead to significant advancements in treating neurological conditions, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Haseley, Maryclaire — University of Rochester
- Study coordinator: Haseley, Maryclaire
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.