Understanding how a protein affects the cell envelope of tuberculosis bacteria and its resistance to antibiotics
Official title: Rv3802c function in mycobacterial cell envelope remodeling, barrier properties, and antibiotic susceptibility
Funded at State University New York Stony Brook · NIH-10901329 · Data updated 2026-11-12
This study is looking at a protein called Rv3802c in the tuberculosis bacteria to understand how it affects the bacteria's protective outer layer and how well antibiotics can work against it, with the hope of finding better treatments for people with TB.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,306 |
| NIH project number | 1F30AI179077-01A1 |
| Project ID | NIH-10901329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with Mycobacterium tuberculosis or those at high risk of developing tuberculosis.
✕Less likely to help
Patients with non-mycobacterial infections or those not infected with tuberculosis may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, Rv3802c, in the structure and function of the cell envelope of Mycobacterium tuberculosis, the bacteria that causes tuberculosis (TB). By studying how Rv3802c influences the cell envelope's barrier properties and its susceptibility to antibiotics, the research aims to identify new therapeutic strategies to combat TB. The approach involves characterizing the biological function of Rv3802c and its impact on membrane fluidity and permeability, which are crucial for antibiotic effectiveness. This could lead to innovative ways to enhance treatment options for patients suffering from TB.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for tuberculosis, making it easier to combat this widespread and challenging infection.
How similar studies have gone: Previous research has shown promise in targeting bacterial cell envelope properties to enhance antibiotic effectiveness, suggesting that this approach could yield significant advancements.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Sakarin, Isabel Jantana — State University New York Stony Brook
- Study coordinator: Sakarin, Isabel Jantana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.