Understanding how a protein affects infection-causing bacteria.
Official title: Modulation of Agr system by ClpC chaperone in S. aureus
Funded at Univ of Arkansas for Med Scis · NIH-10796840 · Data updated 2026-11-12
This study is looking at how a specific protein called ClpC helps the bacteria Staphylococcus aureus, which can cause infections, to turn on its harmful genes, and it aims to find new ways to fight these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $229,500 |
| NIH project number | 5R21AI168850-02 |
| Project ID | NIH-10796840 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of or currently suffering from infections caused by Staphylococcus aureus.
✕Less likely to help
Patients with infections caused by other types of bacteria or those not affected by Staphylococcus aureus may not benefit from this research.
What this research studies
This research investigates the role of the ClpC chaperone protein in regulating virulence genes in Staphylococcus aureus, a significant human pathogen. By exploring how ClpC interacts with other regulatory proteins, the study aims to uncover the complex network that controls the bacteria's ability to cause infections. The researchers will utilize various biological assays to analyze gene expression and the effects of ClpC on the bacteria's virulence factors. This work is crucial for developing new strategies to combat infections caused by S. aureus.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the severity of infections caused by Staphylococcus aureus.
How similar studies have gone: Previous research has shown success in understanding bacterial virulence regulation, making this approach promising for further advancements.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Lee, Chia Y. — Univ of Arkansas for Med Scis
- Study coordinator: Lee, Chia Y.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.