Understanding how a protein affects immune signaling in blood cells
Official title: Regulation of Protein Kinase C Theta by Phosphorylation
Funded at University of California, San Diego · NIH-11056895 · Data updated 2026-11-12
This study is looking at how certain changes in a protein called PKCθ, which helps control immune responses in blood cells, can affect its activity, with the hope of finding better ways to treat autoimmune diseases and blood cancers.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $41,376 |
| NIH project number | 5F31HL168916-03 |
| Project ID | NIH-11056895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or blood disorders.
✕Less likely to help
Patients with conditions unrelated to immune signaling or blood cell function may not benefit from this research.
What this research studies
This research investigates the role of phosphorylation in regulating the activity of protein kinase C Theta (PKCθ), a key player in immune signaling found in blood cells. By examining how specific phosphorylation sites influence PKCθ's function, the study aims to uncover mechanisms that could lead to better understanding and treatment of autoimmune diseases and blood cancers. The research employs advanced techniques such as phosphoproteomics to analyze changes in PKCθ in response to cellular stimulation. Patients may benefit from insights gained into how immune responses can be modulated in various conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases and blood cancers.
How similar studies have gone: Previous research has shown promising results in understanding immune signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Hodapp, Stefanie Jill — University of California, San Diego
- Study coordinator: Hodapp, Stefanie Jill
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.