Understanding how a protein affects immune responses in T-cells
Official title: SIRPgamma: a novel checkpoint regulator of effector responses from human T-cells
Funded at Texas Woman's University · NIH-10576554 · Data updated 2026-11-12
This study is looking at a protein called SIRPgamma to understand how it affects the immune system in people, especially why some folks have healthy immune responses while others struggle with autoimmune diseases, which could help improve treatments and vaccine effectiveness for everyone.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Woman's University NIH-funded |
| Lab location | 1 site (Denton, United States) |
| Project start | November 11, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $378,837 |
| NIH project number | 1R15AI169400-01A1 |
| Project ID | NIH-10576554 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases such as type 1 diabetes or multiple sclerosis, as well as those interested in understanding their immune response to vaccines.
✕Less likely to help
Patients without autoimmune conditions or those not interested in immune response mechanisms may not benefit from this research.
What this research studies
This research investigates the role of a protein called SIRPgamma in regulating immune responses from human T-cells. By examining how variations in SIRPgamma expression influence the immune system, the study aims to uncover why some individuals experience balanced immune responses while others suffer from autoimmune conditions. The approach involves analyzing T-cells from different individuals to see how their SIRPgamma levels correlate with immune function and disease susceptibility. This could lead to new insights into managing autoimmune diseases and improving vaccine responses.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for autoimmune diseases and improved vaccine efficacy.
How similar studies have gone: Previous research has shown that understanding immune regulatory proteins can lead to significant advancements in treating autoimmune diseases, suggesting this approach has potential for success.
Where this research is happening
-
Texas Woman's University
Denton, United States Active
Researchers
- Principal investigator: Sinha, Sushmita — Texas Woman's University
- Study coordinator: Sinha, Sushmita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.