Understanding how a protein affects B cell development and lymphoma
Functions and mechanisms of transcriptional coactivator OCA-B in B cell development and lymphomagenesis
This study is looking at a protein called OCA-B to see how it helps B cells, which are important for our immune system, grow and work properly, and it could also help us understand how some blood cancers, like Burkitt's lymphoma, develop.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10817664 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called OCA-B in the development of B cells, which are crucial for a healthy immune system. It focuses on how OCA-B influences the formation of germinal centers, where B cells mature and produce antibodies. By studying the mechanisms behind OCA-B's function, researchers aim to uncover its impact on both normal immune responses and the progression of certain lymphomas, such as Burkitt's lymphoma. The approach includes in vivo studies to observe OCA-B's interactions and effects on gene regulation in B cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune disorders or those diagnosed with B cell lymphomas.
Not a fit: Patients with non-B cell related cancers or those without autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for autoimmune diseases and lymphomas, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the roles of transcriptional coactivators in immune cell development, suggesting potential for success in this area.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Roeder, Robert G — Rockefeller University
- Study coordinator: Roeder, Robert G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.