Understanding how a protein affects B cell development and antibody production
Official title: FCRL1 in B cell differentiation
Funded at Miami University Oxford · NIH-10730705 · Data updated 2026-11-12
This study is looking at how a protein called FCRL1 helps B cells, which are important for making antibodies to fight infections and respond to vaccines, work better, and it could lead to ways to boost our immune responses in different illnesses.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Miami University Oxford NIH-funded |
| Lab location | 1 site (Oxford, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $411,695 |
| NIH project number | 1R15AI174170-01A1 |
| Project ID | NIH-10730705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or those who may benefit from improved vaccine responses.
✕Less likely to help
Patients with conditions unrelated to B cell function or antibody production may not receive any benefit from this research.
What this research studies
This research investigates the role of a specific protein, FCRL1, in the development and function of B lymphocytes, which are crucial for producing antibodies in response to infections and vaccinations. By studying how FCRL1 influences B cell activation and differentiation, the research aims to uncover the mechanisms that optimize antibody responses. The study will utilize a model system and genetically modified mice to track B cell behavior during the immune response, particularly in specialized structures called germinal centers. This approach could provide insights into improving immune responses in various diseases.
Why it matters
Potential benefit: If successful, this research could lead to enhanced vaccine efficacy and better treatments for autoimmune diseases by improving our understanding of antibody production.
How similar studies have gone: Previous research has shown promising results in understanding B cell differentiation and antibody responses, indicating that this approach has potential for success.
Where this research is happening
-
Miami University Oxford
Oxford, United States Active
Researchers
- Principal investigator: Wilson, Timothy James — Miami University Oxford
- Study coordinator: Wilson, Timothy James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.