Understanding how a key protein influences the development of natural killer cells in humans
Bcl11b: A Master Transcription Factor Controlling Human NK Cell Development
This study is looking at how a protein called Bcl11b helps our immune cells, known as natural killer (NK) cells, grow and work better to fight infections and cancer, and it’s for anyone interested in understanding how we can improve treatments using these important cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11083718 on NIH RePORTER |
What this research studies
This research investigates the role of the Bcl11b protein in the development of natural killer (NK) cells, which are crucial for fighting infections and cancer. By analyzing blood samples from individuals, the researchers aim to uncover how Bcl11b and other transcription factors influence NK cell differentiation. The study employs advanced techniques such as flow cytometry and sequencing to map out the genetic networks involved in NK cell development. This knowledge could lead to improved immunotherapies that harness NK cells for treating various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with advanced cancer or viral infections who may benefit from enhanced NK cell therapies.
Not a fit: Patients with conditions unrelated to NK cell function or those who do not have advanced cancer or viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of immunotherapies for cancer and viral infections by optimizing NK cell function.
How similar studies have performed: Previous research has shown promise in understanding NK cell biology, but the specific role of Bcl11b in human NK cell development is a novel area of investigation.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Cichocki, Frank — University of Minnesota
- Study coordinator: Cichocki, Frank
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.