Understanding how a key protein controls immune responses
The landscape of NFκB transcription dynamics
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11117095
This project aims to uncover how a vital protein called NFκB interacts with our DNA to regulate immune system activity, which is important for conditions like AIDS and autoimmune diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11117095 on ClinicalTrials.gov |
What this research studies
Our bodies have special proteins called transcription factors, like NFκB, that tell our genes what to do, especially in response to stress or infection. We are exploring the complex ways these proteins attach to DNA, which is more flexible than previously thought. By combining advanced theories with laboratory experiments, we hope to understand these interactions better. This knowledge is crucial because NFκB plays a big role in controlling hundreds of genes involved in our immune system and how cells grow.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but could eventually benefit individuals with autoimmune diseases, inflammatory disorders, or AIDS.
Not a fit: Patients whose conditions are not related to NFκB activity or immune system regulation may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to target NFκB, potentially offering new treatments for autoimmune diseases, inflammatory conditions, and even AIDS.
How similar studies have performed: While the specific approach to understanding NFκB-DNA binding is novel, previous research has established NFκB's critical role in immune and inflammatory responses.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOMIVES, ELIZABETH A. — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: KOMIVES, ELIZABETH A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, Autoimmune Diseases