Understanding how a key glycolysis enzyme is controlled in cells and its role in cancer and neurodegeneration
Official title: Structure and function of glycolytic enzymes and their cellular regulation
Funded at West Virginia University · NIH-11387552 · Data updated 2026-11-12
A research project will study how the enzyme PFK1, a regulator of glucose metabolism, is controlled in liver cells and how this affects breast cancer cell movement and disease-related metabolism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $382,500 |
| NIH project number | 5R35GM158392-02 |
| Project ID | NIH-11387552 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with breast cancer or neurodegenerative or metabolic disorders could benefit from advances in understanding PFK1 regulation and its impact on disease biology.
✕Less likely to help
This basic science project does not involve patient recruitment or a direct intervention for participants.
What this research studies
This project looks at how a major glycolysis enzyme, PFK1, is turned on and off inside cells and how it forms structures that influence glucose use. The researchers will study the liver version of PFK1 in lab tests and in liver cells to see how its spatial arrangement affects metabolism. They will also explore how a metabolic complex influences the movement of breast cancer cells. Using advanced imaging, biochemical methods, and new molecular tools, the work aims to map when and where PFK1 changes its activity in disease-relevant settings.
Why it matters
Potential benefit: If successful, this work could reveal new ways to modulate cell metabolism and cancer cell behavior, potentially informing future therapies.
How similar studies have gone: Previous work has shown that glycolytic enzymes are tightly regulated in cells, but detailed spatial-temporal mechanisms are still being uncovered; this study follows and expands on those lines of research.
Where this research is happening
-
West Virginia University
Morgantown, United States Active
Researchers
- Principal investigator: Webb, Bradley a — West Virginia University
- Study coordinator: Webb, Bradley a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.