Understanding how a gene regulator may help fight glioblastoma
Official title: Determining the Mechanisms of RING1- and YY1-Binding Protein (RYBP) Function and Dysregulation in Glioblastoma Cells
Funded at Winthrop University · NIH-11398012 · Data updated 2026-11-12
Scientists are studying how a protein called RYBP affects glioblastoma cells to see if boosting this protein could slow down tumor growth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Winthrop University NIH-funded |
| Lab location | 1 site (Rock Hill, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $192,456 |
| NIH project number | 5R16NS141721-03 |
| Project ID | NIH-11398012 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable in this lab-based study; not recruiting patients yet.
✕Less likely to help
No direct patient participation at this stage.
What this research studies
Glioblastoma is a deadly brain cancer with few effective treatments. The project will modify human glioblastoma cells and normal brain cells in the lab to see how changing RYBP levels changes cell behavior like growth and movement. Researchers will use RNA sequencing to map which genes RYBP controls and will examine changes in how the genome is read and organized in these cancer cells. The aim is to uncover mechanisms that could point to new therapeutic strategies for GBM in the future.
Why it matters
Potential benefit: If successful, this work could identify new targets or pathways for therapies aimed at slowing or stopping GBM growth.
How similar studies have gone: Previous work suggests RYBP has tumor-suppressive effects in several cancers, but its role in GBM is not yet clear.
Where this research is happening
-
Winthrop University
Rock Hill, United States Active
Researchers
- Principal investigator: Stovall, Daniel Brooks — Winthrop University
- Study coordinator: Stovall, Daniel Brooks
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.