Understanding how a brain signaling pathway affects the body's internal clock
Mammalian target of rapamycin signaling and the suprachiamatic circadian clock
This study is exploring how a specific pathway in the brain helps control our body's internal clock, which affects our sleep and daily rhythms, and it's designed for anyone interested in understanding how our bodies stay in sync with day and night.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10878903 on NIH RePORTER |
What this research studies
This research investigates the role of the mammalian target of rapamycin (mTOR) signaling pathway in regulating the circadian clock located in the brain's suprachiasmatic nucleus (SCN). By manipulating specific components of the mTOR pathway through genetic and pharmacological methods, the study aims to uncover how these signals influence gene expression and protein synthesis that synchronize the body's internal clock with external environmental cues. The research employs a multidisciplinary approach, assessing molecular, cellular, and behavioral aspects of circadian function in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing circadian rhythm disruptions, such as those with sleep disorders or mood disorders linked to circadian dysregulation.
Not a fit: Patients with stable circadian rhythms or those not experiencing any sleep-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for circadian rhythm disorders, improving sleep quality and overall health.
How similar studies have performed: Previous research has shown promising results in understanding the mTOR pathway's role in various biological processes, suggesting that this approach may yield valuable insights into circadian regulation.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Cao, Ruifeng (Ray) — Rutgers Biomedical and Health Sciences
- Study coordinator: Cao, Ruifeng (Ray)
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.