Understanding how a brain protein affects immune responses
Determining the mechanism of alpha-synuclein dependent innate immune responses in the brain
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10820430
This study is looking at how a protein called alpha-synuclein, which is connected to Parkinson's disease, affects the brain's ability to fight off infections and inflammation, and it's for anyone interested in understanding more about how we can better treat neurodegenerative diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10820430 on ClinicalTrials.gov |
What this research studies
This research investigates the role of alpha-synuclein, a protein linked to Parkinson's disease, in the brain's immune responses. It aims to uncover how this protein influences the signaling pathways that help protect neurons from infections and inflammation. By using advanced techniques like induced pluripotent stem cells and CRISPR technology, the researchers will explore the mechanisms by which alpha-synuclein modulates immune signaling in the central nervous system. This could lead to new insights into neurodegenerative diseases and their treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodegenerative diseases, particularly those with Parkinson's disease or related conditions.
Not a fit: Patients with acute infections or non-neurological conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases by enhancing our understanding of immune responses in the brain.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in the brain, but this specific approach focusing on alpha-synuclein is relatively novel.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BECKHAM, JOHN DAVID — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: BECKHAM, JOHN DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease