Understanding how a bacterium escapes immune response and causes disease
Composition, Atomic Structure and Function of the Francisella Type 6 Secretion System, a Distinct Subtype Essential for Phagosomal Escape, Intracellular Replication, and Virulence
This study is looking at how a specific system used by the bacteria that cause tularemia helps them avoid our immune system, with the goal of finding better ways to treat and prevent infections for people who might get sick from it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10891678 on NIH RePORTER |
What this research studies
This research investigates the Francisella Type VI Secretion System (T6SS), a mechanism used by the bacterium Francisella tularensis to escape the immune system and replicate within host cells. By utilizing advanced imaging techniques like cryo-electron microscopy, the researchers aim to uncover the atomic structure and function of this system. Understanding how T6SS operates will help in developing effective treatments and vaccines against infections caused by this highly virulent bacterium. The research focuses on the composition and mechanisms of T6SS to better understand its role in disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of exposure to Francisella tularensis, particularly those in endemic areas or with occupational exposure.
Not a fit: Patients who are not at risk of infection from Francisella tularensis or similar bacterial pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and vaccines for infections caused by Francisella tularensis and similar bacteria.
How similar studies have performed: Previous research on the Type VI Secretion System in other bacteria has shown promising results, indicating that this approach could yield significant insights into bacterial pathogenesis.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Horwitz, Marcus Aaron — University of California Los Angeles
- Study coordinator: Horwitz, Marcus Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.