Understanding heart inflammation and dysfunction caused by Pseudomonas aeruginosa infections
Molecular mechanism of cardiac inflammation and dysfunction in Pseudomonas aeruginosa infection
This study looks at how infections from a common hospital germ called Pseudomonas aeruginosa can cause heart problems, especially in patients with serious conditions like pneumonia, and it hopes to find new ways to help prevent these heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10654794 on NIH RePORTER |
What this research studies
This research investigates how infections from Pseudomonas aeruginosa, a common hospital-acquired bacterium, lead to inflammation and dysfunction in the heart. It focuses on the mechanisms by which these infections affect heart cells, particularly during severe cases like ventilator-associated pneumonia. By studying the cellular responses and inflammatory processes involved, the research aims to identify potential targets for new treatments that could prevent heart complications in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients in intensive care units who are experiencing or at risk of ventilator-associated pneumonia and related cardiac complications.
Not a fit: Patients with non-bacterial infections or those not experiencing cardiac issues related to pneumonia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent heart dysfunction in patients suffering from severe bacterial infections.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can improve outcomes in similar conditions, suggesting potential for success in this approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Rajaram, Murugesan — Ohio State University
- Study coordinator: Rajaram, Murugesan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.