Understanding heart development and disease using human stem cells
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
This study is looking at how heart cells and the heart's inner lining work together, especially in understanding a serious heart condition called hypoplastic left heart syndrome (HLHS), by using human stem cells to learn more about the changes caused by NOTCH1 mutations that can lead to heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11013362 on NIH RePORTER |
What this research studies
This research investigates how interactions between heart cells and the inner lining of the heart affect heart development and diseases, particularly focusing on a severe congenital heart defect known as hypoplastic left heart syndrome (HLHS). By using human stem cells, the researchers aim to uncover the mechanisms behind NOTCH1 mutations that lead to heart malformations. The study will explore how these mutations disrupt communication between different heart cell types, which is crucial for proper heart formation. This approach may provide insights that are not achievable with traditional animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns diagnosed with hypoplastic left heart syndrome or related congenital heart defects.
Not a fit: Patients with congenital heart defects not related to NOTCH1 mutations or those who are older than newborns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for congenital heart defects like HLHS.
How similar studies have performed: Previous research has shown promise in using stem cell models to study heart diseases, indicating that this approach may yield valuable insights.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Zhao, Mingtao — Research Inst Nationwide Children's Hosp
- Study coordinator: Zhao, Mingtao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.