Understanding heart and inflammation issues in children after cardiac arrest
Official title: Assessment of Myocardial Dysfunction and Inflammation after Pediatric Cardiac Arrest
Funded at Children's Hosp of Philadelphia · NIH-10947229 · Data updated 2026-11-12
This study looks at how surviving cardiac arrest affects children's hearts and inflammation, aiming to understand their recovery better and help improve care for young patients who have gone through this experience.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $145,910 |
| NIH project number | 1K23HL175123-01 |
| Project ID | NIH-10947229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill children who have experienced cardiac arrest.
✕Less likely to help
Patients who have not experienced cardiac arrest or are outside the pediatric age range may not benefit from this research.
What this research studies
This research investigates the effects of cardiac arrest on children's hearts and inflammation levels. It focuses on children who survive cardiac arrest, examining how their hearts function and how inflammation may affect their recovery. The study will involve advanced imaging techniques to assess heart function and blood tests to measure inflammation markers. By analyzing these factors in a larger group of critically ill children, the research aims to identify patterns that could improve outcomes for young patients.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for children recovering from cardiac arrest, potentially improving their heart function and overall recovery.
How similar studies have gone: While pediatric cardiac arrest is a relatively understudied area, preliminary data suggest that similar approaches have shown promise in understanding post-cardiac arrest outcomes.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Gardner, Monique-Anne — Children's Hosp of Philadelphia
- Study coordinator: Gardner, Monique-Anne
Related research
Other NIH-funded projects on the same topics.
-
Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.