Understanding genetic factors that influence PTSD development
Integration of multi-omic data and biological validation for gene prioritization in PTSD risk loci
This study is looking at how certain genes might make some people more likely to develop posttraumatic stress disorder (PTSD) after a traumatic event, using data from veterans and special brain cells to better understand the biology behind PTSD.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-11045340 on NIH RePORTER |
What this research studies
This research investigates the biological factors that contribute to the development of posttraumatic stress disorder (PTSD), focusing on genetic variations that increase risk. By integrating various types of biological data, including genomic, epigenomic, and transcriptomic information, the study aims to uncover how these genetic risk factors operate at a molecular level. The research utilizes data from the Million Veteran Program and experimental studies involving human induced pluripotent stem cell neurons to bridge the gap between genetics and PTSD. This comprehensive approach seeks to enhance our understanding of PTSD biology and its underlying mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of trauma who may be at risk for developing PTSD.
Not a fit: Patients who do not have a history of trauma or those without genetic predispositions to PTSD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of individuals at risk for PTSD and the development of targeted interventions.
How similar studies have performed: Previous research has shown promise in integrating multi-omic data to understand complex conditions, suggesting potential for success in this novel approach.
Where this research is happening
San Diego, United States
- VA San Diego Healthcare System — San Diego, United States (Active)
Researchers
- Principal investigator: Maihofer, Adam Xavier — VA San Diego Healthcare System
- Study coordinator: Maihofer, Adam Xavier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.