Understanding genetic factors in lupus
Characterization of SLE-susceptibility loci on mouse chromosome 1
This research explores specific genetic changes that may contribute to lupus and how they affect the body's immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11133034 on NIH RePORTER |
What this research studies
Our bodies have special immune cells called T cells that help fight off infections, but sometimes they can mistakenly attack healthy tissues, as seen in lupus. This project looks at a particular gene, Pbx1, which has a slightly different version in people with lupus. We are learning how this altered gene might lead to problems with other immune cells, called Tregs, which are important for keeping the immune system balanced. By understanding these genetic links, we hope to uncover new ways to help manage autoimmune conditions.
Who could benefit from this research
Good fit: This foundational research is not currently recruiting patients for direct participation, but it is highly relevant to individuals living with lupus or other autoimmune conditions.
Not a fit: Patients without lupus or related autoimmune conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of lupus and potentially new ways to treat or prevent the disease by targeting specific genetic pathways.
How similar studies have performed: This work builds upon previous findings that have identified genetic variations linked to lupus and immune cell dysfunction, establishing a novel role for Pbx1 in maintaining immune balance.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Morel, Laurence — University of Texas Hlth Science Center
- Study coordinator: Morel, Laurence
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.