Understanding genetic factors in complex blood vessel diseases
Functional genomics investigation of pleiotropic vascular disease loci
This research aims to uncover how our genes contribute to common heart and blood vessel conditions like coronary artery disease and heart attacks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11082333 on NIH RePORTER |
What this research studies
Many people worldwide are affected by serious blood vessel diseases such as coronary artery disease and heart attacks, which are influenced by both our genes and our environment. We urgently need new ways to prevent and treat these conditions by targeting the root causes within the blood vessel walls. This project uses advanced techniques to look closely at human coronary artery cells, specifically smooth muscle cells, to understand how genetic differences affect their function. By studying these cells, we hope to learn how genetic changes lead to disease and identify new targets for future treatments.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the genetic causes of atherosclerotic cardiovascular disease, coronary artery disease, myocardial infarction, or coronary artery calcification.
Not a fit: Patients seeking immediate clinical interventions or direct participation in a treatment trial would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new treatments and preventative measures for common vascular diseases by identifying the specific genetic pathways involved.
How similar studies have performed: Previous large-scale genetic studies have identified many genetic links to vascular diseases, and this project builds upon those findings to understand their biological impact.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Miller, Clint L — University of Virginia
- Study coordinator: Miller, Clint L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.