Understanding genetic factors in Alzheimer's disease in families from Jalisco, Mexico
Phenotype and Genotype of Autosomal Dominant Alzheimer's Disease in Jalisco, Mexico
This study is looking at families in Jalisco, Mexico, who have a genetic risk for Alzheimer's disease, to better understand how the disease develops before symptoms appear, which could help find new ways to treat or prevent it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10897960 on NIH RePORTER |
What this research studies
This research investigates families in Jalisco, Mexico, who are genetically predisposed to autosomal dominant Alzheimer's disease (ADAD) due to specific mutations. By studying these families, researchers aim to identify the disease's phenotype and track changes during the presymptomatic phase, which could help in understanding how the disease progresses. The study will involve collaboration with local clinics to ensure accurate data collection and analysis. This approach allows for the evaluation of other factors that may influence the disease's course, potentially leading to new insights into treatment and prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from families in Jalisco with known genetic mutations linked to autosomal dominant Alzheimer's disease.
Not a fit: Patients without a genetic predisposition to Alzheimer's disease or those not from the studied families may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Alzheimer's disease, particularly for those with a genetic predisposition.
How similar studies have performed: Previous research on genetically predisposed populations has shown success in understanding Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Ringman, John M — University of Southern California
- Study coordinator: Ringman, John M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.