Understanding genetic differences that affect immune diseases
Biophysical and functional characterization of immune-related regulatory elements and noncoding variants
['FUNDING_R01'] · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · NIH-10796874
This study is looking at how certain genetic differences can affect the way your immune system works, which might help us understand autoimmune diseases better and find more personalized treatments just for you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10796874 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic variations, particularly in non-coding regions of the genome, influence immune gene expression and contribute to autoimmune diseases. By employing advanced techniques like Massively Parallel Reporter Assays (MPRAs) and the CASCADE approach, the study aims to identify which genetic variants are responsible for altering immune responses. This could lead to a better understanding of the mechanisms behind autoimmune conditions and help in developing targeted therapies. Patients may benefit from insights that could inform personalized treatment strategies based on their genetic makeup.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases who have genetic variations that may influence their condition.
Not a fit: Patients without autoimmune diseases or those whose conditions are not influenced by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for autoimmune diseases by identifying specific genetic targets.
How similar studies have performed: Previous research has shown promise in using high-throughput approaches to understand genetic influences on diseases, indicating potential success for this study.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIGGERS, TREVOR — BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- Study coordinator: SIGGERS, TREVOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autoimmune disorder, autoimmunity disease, Autoimmune Diseases