Understanding genetic differences in how opioids affect breathing in mice
Genetic Variation in Opioid Induced Respiratory Depression in Mice
This study is looking at how our genes might affect how we react to opioids, which can sometimes cause breathing problems and overdose, and it's being done in mice to help find safer ways to manage pain and improve treatments for opioid overdose.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-10771959 on NIH RePORTER |
What this research studies
This research investigates how genetic variations influence the risk of respiratory depression caused by opioids, which can lead to overdose and death. By studying mice, the researchers aim to uncover the molecular mechanisms that determine individual responses to opioids. The goal is to identify specific genetic factors that contribute to varying sensitivities to opioid effects, which could lead to safer pain management strategies and alternatives to current overdose treatments like naloxone. This work could ultimately help in developing personalized approaches to opioid therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of opioid use or those who are prescribed opioids for pain management.
Not a fit: Patients who do not use opioids or have no history of pain management with opioids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer opioid prescriptions and better treatment options for patients at risk of overdose.
How similar studies have performed: Other research has shown promise in understanding genetic factors related to opioid responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Bubier, Jason a — Jackson Laboratory
- Study coordinator: Bubier, Jason a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.