Understanding gene networks that affect heart development
Gene regulatory networks for heart development
This study is looking into how certain genes might cause congenital heart defects, which are heart problems babies are born with, to help find better ways to diagnose and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10764324 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to congenital heart defects (CHDs), which are serious birth defects affecting heart structure. By studying specific genes and their regulatory networks, the research aims to uncover how mutations in these genes lead to heart development issues. The team uses advanced models, including induced pluripotent stem cells and mouse models, to analyze the effects of gene dosage on heart formation. This approach could help identify new diagnostic and treatment strategies for individuals affected by CHDs.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital heart defects or those with a family history of such conditions.
Not a fit: Patients without congenital heart defects or those whose conditions are unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and therapies for congenital heart defects, potentially enhancing patient outcomes.
How similar studies have performed: Other research has shown promise in understanding genetic contributions to congenital heart defects, indicating that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Bruneau, Benoit Gaetan — J. David Gladstone Institutes
- Study coordinator: Bruneau, Benoit Gaetan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.