Understanding gene expression in heart disease and liver conditions
Genomics Bioinformatics
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10908530
This study is looking at how changes in genes, diet, and medications can affect heart and liver health, specifically for people dealing with atherosclerosis and NASH, to help find better ways to understand and treat these conditions.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10908530 on ClinicalTrials.gov |
What this research studies
This research focuses on using advanced sequencing techniques to explore how genetic, dietary, and medication changes affect gene expression related to atherosclerosis and non-alcoholic steatohepatitis (NASH). By analyzing various tissues and cell types, the project aims to uncover the biological mechanisms that contribute to these conditions. The research includes preparing and sequencing genetic material and applying bioinformatics tools to interpret the data, which could lead to new insights into disease progression and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerosis or NASH.
Not a fit: Patients with unrelated cardiovascular conditions or those not affected by atherosclerosis or NASH may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for patients with atherosclerosis and NASH.
How similar studies have performed: Previous research using similar genomic and bioinformatics approaches has shown promise in understanding complex diseases, indicating potential for success in this area.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BENNER, CHRISTOPHER W — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: BENNER, CHRISTOPHER W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease