Understanding Gene Activity in Lupus
Gene Transcription in SLE
This research explores how specific genes contribute to the development and progression of lupus, an autoimmune condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11103212 on NIH RePORTER |
What this research studies
This project delves into the complex genetic processes that lead to the immune system mistakenly attacking the body in systemic lupus erythematosus (SLE). Researchers have identified molecular pathways in both people and mice with lupus that affect the production of key immune proteins, which are already being targeted in clinical trials. The current focus is on a gene regulator called ADAM9, which appears to control immune responses and inflammation in various organs. By studying human cells and tissues, along with advanced mouse models, the team aims to clarify how ADAM9 drives autoimmunity in lupus and how factors like low oxygen in tissues might increase its activity, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to understand the underlying biology of systemic lupus erythematosus.
Not a fit: Patients not diagnosed with systemic lupus erythematosus would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could reveal new targets for medications that help regulate the immune system and reduce organ damage for people living with lupus.
How similar studies have performed: This research builds upon previous findings in both human and mouse studies that identified key molecular mechanisms in lupus, but the role of ADAM9 in this context is a newer area of focus.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Tsokos, George C — Beth Israel Deaconess Medical Center
- Study coordinator: Tsokos, George C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.