Understanding flares and remission in colitis
Mechanisms associated with flares and remission in colitis
This research explores how certain food colorants might contribute to inflammatory bowel diseases like colitis, especially in people with a genetic predisposition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11103147 on NIH RePORTER |
What this research studies
We are looking into how common food additives, specifically Red 40, might trigger or worsen colitis. Our initial findings in mice suggest that Red 40 can promote colitis, particularly in those with a specific genetic background related to the immune system. This effect seems to involve gut bacteria and certain immune cells. By understanding these connections, we hope to uncover environmental factors that play a role in inflammatory bowel diseases.
Who could benefit from this research
Good fit: This research is most relevant to individuals living with inflammatory bowel diseases, particularly those seeking to understand environmental or dietary triggers for their condition.
Not a fit: Patients without inflammatory bowel diseases or those whose condition is not influenced by dietary factors may not directly benefit from these specific findings.
Why it matters
Potential benefit: If successful, this work could help identify dietary triggers for colitis, potentially leading to new ways to prevent flares or manage the condition through diet.
How similar studies have performed: This research presents novel findings regarding the role of Red 40 in promoting colitis in specific mouse models, suggesting a new area of investigation.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Lira, Sergio a. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lira, Sergio a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.