Understanding fatigue in health and after COVID-19
Official title: Neurobiological Mechanisms of Fatigue in Health and after COVID-19
Funded at Hugo W. Moser Res Inst Kennedy Krieger · NIH-10872162 · Data updated 2026-11-12
This study is looking at how fatigue affects people recovering from COVID-19, trying to understand what makes them feel tired and how hard they’re willing to work, so we can find better ways to help those who are struggling with this issue.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $99,113 |
| NIH project number | 5K99NS133961-02 |
| Project ID | NIH-10872162 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing severe fatigue after COVID-19 as well as healthy individuals for comparative analysis.
✕Less likely to help
Patients who do not experience fatigue or those with acute COVID-19 symptoms may not benefit from this research.
What this research studies
This research investigates the neurobiological mechanisms behind fatigue, particularly in individuals recovering from COVID-19. It aims to explore how fatigue manifests in terms of weariness, perceived effort, and willingness to exert effort. By employing innovative neuromuscular and computational methods, the study seeks to objectively measure these aspects of fatigue in both healthy individuals and those experiencing post-acute sequelae of SARS-CoV-2 infection (PASC). The findings could lead to better understanding and treatment options for fatigue, which is often debilitating and poorly managed.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating fatigue in patients, especially those recovering from COVID-19.
How similar studies have gone: Previous research has shown promise in understanding fatigue through various neurobiological approaches, but this specific investigation into PASC-related fatigue is relatively novel.
Where this research is happening
-
Hugo W. Moser Res Inst Kennedy Krieger
Baltimore, United States Active
Researchers
- Principal investigator: Casamento Moran, Agostina — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Casamento Moran, Agostina
Related research
Other NIH-funded projects on the same topics.
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Understanding fatigue in COVID-19 and beyond
This grant aims to uncover why fatigue happens in people after COVID-19 and in other conditions, using new brain and body measurements to find clearer targets for treatment.
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What causes fatigue in long COVID and in healthy people
This project looks at how the brain and muscles create different kinds of fatigue in people with long COVID and in people without COVID.
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Improving fatigue and muscle function in older adults recovering from COVID-19 through diet.
This study is looking at how a healthy diet full of anti-inflammatory foods can help older adults who are dealing with lingering symptoms after COVID-19, like tiredness and muscle weakness, to feel better and regain their strength over 16 weeks.
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Telehealth exercise program to help rural breast cancer survivors fight fatigue
A telehealth exercise program is being tested to reduce cancer-related fatigue in rural breast cancer survivors.
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Structural factors linking minimum wage, COVID-19, and community violence
A long-term study will explore whether higher minimum wages and pandemic-related economic factors are connected to changes in violence in US communities.
-
COVID-19 healthcare disruptions and heart health inequities in NYC adults with multiple conditions
This project looks at how COVID-19-related gaps in care affected heart health in adults with several chronic conditions in New York City.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.