Understanding Exercise for Muscle Loss in Liver Disease
Mechanistic basis of exercise responses in liver disease
This research explores how exercise helps patients with liver disease who are losing muscle, aiming to find better ways to keep them strong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11158615 on NIH RePORTER |
What this research studies
Many people with advanced liver disease, like cirrhosis, experience muscle loss and weakness, making daily activities harder. While exercise can help improve muscle and fitness, we don't fully understand why it works or how to make it most effective for these patients. This project will look closely at the body's responses to different types of exercise, including how gut bacteria and certain substances like ammonia might play a role. Our goal is to uncover the specific ways exercise benefits muscle health in liver disease, which could lead to more personalized and successful exercise plans.
Who could benefit from this research
Good fit: Patients with cirrhosis experiencing muscle loss and reduced exercise capacity would be the focus of this type of research.
Not a fit: Patients without liver disease or muscle loss would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective and personalized exercise programs that improve muscle strength, physical ability, and overall health for patients with liver disease.
How similar studies have performed: While exercise is known to improve some aspects of muscle and fitness in cirrhosis, the exact mechanisms behind these improvements are not yet fully understood.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Dasarathy, Srinivasan — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dasarathy, Srinivasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.