Understanding early kidney cell injury in a specific genetic kidney disease
Official title: Early podocyte injury in collagen IV nephropathy
Funded at Ut Southwestern Medical Center · NIH-11171201 · Data updated 2026-11-12
This study is looking at how kidney cells called podocytes get hurt early on in people with collagen IV nephropathies, and it aims to find ways to stop or slow down kidney damage caused by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 9, 2024 |
| Project end | September 5, 2025 |
| Funding year | 2024 |
| Award (this year) | $200,000 |
| NIH project number | 1R56DK139111-01 |
| Project ID | NIH-11171201 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who have been diagnosed with collagen IV nephropathies or related kidney diseases.
✕Less likely to help
Patients with kidney diseases not related to collagen IV mutations may not benefit from this research.
What this research studies
This research investigates the initial stages of injury to podocytes, which are essential cells in the kidneys, specifically in patients with collagen IV nephropathies. By analyzing data from mouse models and comparing it to human kidney disease databases, the researchers aim to identify the earliest points of injury and potential interventions. The goal is to understand how mutations in collagen IV proteins lead to kidney damage and chronic kidney disease, with the hope of finding ways to prevent or delay these outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing kidney damage in patients with collagen IV nephropathies.
How similar studies have gone: Previous research has shown promise in understanding kidney diseases through similar genetic and cellular approaches, suggesting potential for success in this area.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Miller, Richard Tyler — Ut Southwestern Medical Center
- Study coordinator: Miller, Richard Tyler
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.