Understanding early kidney cell injury in a specific genetic kidney disease
Early podocyte injury in collagen IV nephropathy
This study is looking at how kidney cells called podocytes get hurt early on in people with collagen IV nephropathies, and it aims to find ways to stop or slow down kidney damage caused by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11171201 on NIH RePORTER |
What this research studies
This research investigates the initial stages of injury to podocytes, which are essential cells in the kidneys, specifically in patients with collagen IV nephropathies. By analyzing data from mouse models and comparing it to human kidney disease databases, the researchers aim to identify the earliest points of injury and potential interventions. The goal is to understand how mutations in collagen IV proteins lead to kidney damage and chronic kidney disease, with the hope of finding ways to prevent or delay these outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who have been diagnosed with collagen IV nephropathies or related kidney diseases.
Not a fit: Patients with kidney diseases not related to collagen IV mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing kidney damage in patients with collagen IV nephropathies.
How similar studies have performed: Previous research has shown promise in understanding kidney diseases through similar genetic and cellular approaches, suggesting potential for success in this area.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Miller, Richard Tyler — Ut Southwestern Medical Center
- Study coordinator: Miller, Richard Tyler
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.