Understanding early beta-cell dysfunction in type 1 diabetes
Pathways and critical regulators of early beta-cell dysfunction in type 1 diabetes
['FUNDING_R01'] · BATTELLE PACIFIC NORTHWEST LABORATORIES · NIH-10441263
This study is looking at how the cells that produce insulin in people with type 1 diabetes start to struggle long before the disease is diagnosed, and it aims to find new ways to help keep these cells healthy and slow down the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BATTELLE PACIFIC NORTHWEST LABORATORIES (nih funded) |
| Locations | 1 site (RICHLAND, UNITED STATES) |
| Trial ID | NIH-10441263 on ClinicalTrials.gov |
What this research studies
This research investigates the early stages of beta-cell dysfunction in type 1 diabetes (T1D), which occurs years before the disease is clinically diagnosed. By analyzing pancreatic tissue samples from individuals with varying stages of T1D, the study aims to uncover the molecular mechanisms that lead to beta-cell failure. The approach involves advanced proteomics techniques to characterize the proteins expressed in these cells, providing insights into how they respond to their environment. This knowledge could help identify new therapeutic targets to prevent or slow the progression of T1D.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for type 1 diabetes or those recently diagnosed with the condition.
Not a fit: Patients with type 2 diabetes or those who do not have any autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that halt or reverse the onset of type 1 diabetes.
How similar studies have performed: Previous research has shown promise in understanding beta-cell dysfunction in diabetes, but this specific approach using proteomics is relatively novel.
Where this research is happening
RICHLAND, UNITED STATES
- BATTELLE PACIFIC NORTHWEST LABORATORIES — RICHLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QIAN, WEI-JUN — BATTELLE PACIFIC NORTHWEST LABORATORIES
- Study coordinator: QIAN, WEI-JUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder