Understanding different types of lung injury in ARDS
Evolution and resolution of ARDS molecular phenotypes
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11071961
This study is looking at how different types of acute respiratory distress syndrome (ARDS) affect breathing in patients on ventilators, with the goal of finding better ways to treat each person's unique lung issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11071961 on ClinicalTrials.gov |
What this research studies
This research investigates the acute respiratory distress syndrome (ARDS), a serious condition that affects breathing and can lead to high mortality rates. By analyzing blood and lung samples from patients on mechanical ventilation, the study aims to identify distinct biological mechanisms that contribute to different ARDS phenotypes. The researchers will utilize advanced techniques like single cell RNA sequencing and metatranscriptomic sequencing to explore how these phenotypes respond to treatments. This approach could help tailor therapies to individual patients based on their specific lung injury characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome who require mechanical ventilation.
Not a fit: Patients with ARDS who are not on mechanical ventilation or those with other underlying respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for ARDS, potentially reducing mortality and improving recovery rates.
How similar studies have performed: Previous research has shown promise in identifying ARDS phenotypes, but this study aims to deepen understanding of their biological mechanisms, making it a novel approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SARMA, AARTIK — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SARMA, AARTIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome, Airway Disease