Understanding different types of lung injury in ARDS
Official title: Evolution and resolution of ARDS molecular phenotypes
Funded at University of California, San Francisco · NIH-11071961 · Data updated 2026-11-12
This study is looking at how different types of acute respiratory distress syndrome (ARDS) affect breathing in patients on ventilators, with the goal of finding better ways to treat each person's unique lung issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 5, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $186,462 |
| NIH project number | 5K23HL163491-03 |
| Project ID | NIH-11071961 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome who require mechanical ventilation.
✕Less likely to help
Patients with ARDS who are not on mechanical ventilation or those with other underlying respiratory conditions may not benefit from this research.
What this research studies
This research investigates the acute respiratory distress syndrome (ARDS), a serious condition that affects breathing and can lead to high mortality rates. By analyzing blood and lung samples from patients on mechanical ventilation, the study aims to identify distinct biological mechanisms that contribute to different ARDS phenotypes. The researchers will utilize advanced techniques like single cell RNA sequencing and metatranscriptomic sequencing to explore how these phenotypes respond to treatments. This approach could help tailor therapies to individual patients based on their specific lung injury characteristics.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for ARDS, potentially reducing mortality and improving recovery rates.
How similar studies have gone: Previous research has shown promise in identifying ARDS phenotypes, but this study aims to deepen understanding of their biological mechanisms, making it a novel approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Sarma, Aartik — University of California, San Francisco
- Study coordinator: Sarma, Aartik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.