Understanding different types of heart injury and their risk factors
Official title: Contemporary Classification of Myocardial Injury Events in MESA: Defining Distinct Risk Factor Associations with Myocardial Infarction Type 1-5 and Acute Non-Ischemic Myocardial Injury
Funded at Vanderbilt University Medical Center · NIH-10902048 · Data updated 2026-11-12
This study is looking at what causes heart damage, both from blocked blood flow and other reasons, to help us understand how different risk factors affect your heart health, so we can find better ways to prevent and treat heart problems for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 20, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $845,239 |
| NIH project number | 5R01HL158976-04 |
| Project ID | NIH-10902048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of cardiovascular disease or those at high risk for myocardial infarction.
✕Less likely to help
Patients with no history of cardiovascular issues or those who are not at risk for myocardial injury may not benefit from this research.
What this research studies
This research investigates the various causes of myocardial injury, including both ischemic and non-ischemic types, to better understand how different risk factors contribute to these conditions. By analyzing data from over 18,000 clinical events collected in the Multi-Ethnic Study of Atherosclerosis (MESA), the study aims to classify myocardial infarction (MI) subtypes and their associations with traditional and nontraditional risk factors. Patients will benefit from improved knowledge that could lead to better prediction, prevention, and treatment strategies for heart-related events.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients at risk of myocardial injury.
How similar studies have gone: Previous research has shown success in understanding cardiovascular diseases through large cohort studies, indicating that this approach is promising.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Defilippis, Andrew — Vanderbilt University Medical Center
- Study coordinator: Defilippis, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.