Understanding different biological responses in patients with acute respiratory distress syndrome.
Official title: The MUltidimenSional phenotyping In Critical care (MUSIC) Consortium: A pathway to precision medicine at the bedside
Funded at Vanderbilt University Medical Center · NIH-11085917 · Data updated 2026-11-12
This study is looking at how to better understand and group patients with acute respiratory distress syndrome (ARDS) based on their unique biological responses, so that doctors can create more personalized treatments that work best for each individual.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $574,036 |
| NIH project number | 5U01HL168412-03 |
| Project ID | NIH-11085917 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome or related critical illnesses.
✕Less likely to help
Patients with chronic respiratory conditions or those not experiencing acute respiratory distress may not benefit from this research.
What this research studies
This research investigates how patients with acute respiratory distress syndrome (ARDS) can be better classified based on their unique biological responses, which can lead to more personalized treatments. By analyzing large groups of patients, the study aims to identify specific phenotypes, or biological characteristics, that influence how patients respond to various therapies. The research will involve collecting data from a significant number of critically ill patients to understand their long-term outcomes and improve treatment strategies. This approach seeks to move beyond traditional classifications to develop targeted therapies that are tailored to individual patient needs.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for patients suffering from acute respiratory distress syndrome.
How similar studies have gone: Previous research has shown promise in using biological phenotyping to improve treatment outcomes in critical illnesses, suggesting that this approach could be effective.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Ware, Lorraine B — Vanderbilt University Medical Center
- Study coordinator: Ware, Lorraine B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.