Understanding Deep Brain Stimulation for Brain Disorders
Optical Voltage Imaging Analysis of the Cellular and Network Mechanisms of Deep Brain Stimulation
['FUNDING_R01'] · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · NIH-10984956
This research aims to uncover how deep brain stimulation (DBS) works at a cellular level to help people with various brain disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10984956 on ClinicalTrials.gov |
What this research studies
Deep brain stimulation (DBS) is a proven treatment where small electrodes are placed in the brain to help manage symptoms for conditions like Parkinson's disease and other neurological or psychiatric disorders. While DBS is effective, we don't fully understand exactly how it changes brain activity to provide relief. This project uses advanced imaging techniques to look closely at how brain cells and networks respond to DBS. By seeing these tiny electrical changes, we hope to learn the fundamental ways DBS helps the brain function better.
Who could benefit from this research
Good fit: This foundational research is relevant for patients who currently receive deep brain stimulation or those who might be candidates for this therapy in the future.
Not a fit: Patients who do not have a condition treated by deep brain stimulation or who are not candidates for this type of therapy may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective and personalized deep brain stimulation therapies for patients with a range of brain diseases.
How similar studies have performed: Deep brain stimulation is a well-established therapy, but the precise cellular and network mechanisms of how it works are largely unknown, making this approach to understanding them quite novel.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAN, XUE — BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- Study coordinator: HAN, XUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders