Understanding Crohn's Disease Genetics and Treatment Response
Official title: Montreal-Boston Collaborative GRC
Funded at Montreal Heart Institute · NIH-11137760 · Data updated 2026-11-12
This research brings together experts from Montreal and Boston to learn more about the genetic factors that cause Crohn's disease and how different patients respond to treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montreal Heart Institute NIH-funded |
| Lab location | 1 site (Montreal, Canada) |
| Project start | September 30, 2002 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $484,091 |
| NIH project number | 5U01DK062432-25 |
| Project ID | NIH-11137760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for future related studies might include patients with inflammatory bowel disease, particularly Crohn's disease, who are beginning new molecularly-targeted therapies.
✕Less likely to help
Patients who are not diagnosed with inflammatory bowel disease or who are not starting new targeted therapies would likely not directly benefit from this specific research.
What this research studies
Our team is working to uncover the unique genetic differences that contribute to Crohn's disease in various populations, including those in the U.S. We are also following patients with inflammatory bowel disease who are starting new targeted therapies. By collecting genetic information, blood samples, and single-cell data over a year, we hope to understand why some treatments work better for certain individuals. This will help us discover the biological reasons behind the varied experiences of patients with Crohn's disease.
Why it matters
Potential benefit: If successful, this work could lead to more personalized treatments for Crohn's disease, helping doctors choose the best therapy for each patient based on their unique genetic makeup.
How similar studies have gone: This project builds upon the long-standing work of the NIDDK Inflammatory Bowel Disease Genetics Consortium, established in 2002, which has successfully identified genetic variations linked to IBD.
Where this research is happening
-
Montreal Heart Institute
Montreal, Canada Active
Researchers
- Principal investigator: Rioux, John D. — Montreal Heart Institute
- Study coordinator: Rioux, John D.
Related research
Other NIH-funded projects on the same topics.
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Genetic study of Crohn's disease across populations and treatments
Researchers are studying how genetic factors and biological markers influence Crohn’s disease across diverse populations and how patients respond to targeted therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.