Understanding cognitive disabilities in Down syndrome
A new approach to understanding cognitive disabilities in Down syndrome
This study is looking at how changes in brain signaling might affect thinking skills in people with Down syndrome, using a mouse model to help understand the underlying brain processes, so we can learn more about the challenges they face.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10725562 on NIH RePORTER |
What this research studies
This research investigates the cognitive disabilities associated with Down syndrome, which is caused by an extra copy of chromosome 21. It focuses on the GABAergic hypothesis, which suggests that changes in GABA signaling during early brain development may lead to cognitive impairments. Using advanced techniques like two-photon microscopy and electrophysiology, the research aims to uncover the cellular and synaptic mechanisms that affect brain function in individuals with Down syndrome. By studying a mouse model that mimics human Down syndrome, the researchers hope to gain insights into the neurobiological factors contributing to these cognitive challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Down syndrome, particularly those experiencing cognitive disabilities.
Not a fit: Patients without Down syndrome or those who do not exhibit cognitive disabilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to improve cognitive function in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promise in understanding cognitive disabilities through similar neurobiological approaches, but this specific investigation into the GABAergic hypothesis is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Oh, Won Chan — University of Colorado Denver
- Study coordinator: Oh, Won Chan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.