Understanding Circular DNA in Cancer Growth
Investigating the roles of oncogenic extrachromosomal circular DNAs in cancer
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11160595
This research explores how tiny circular pieces of DNA help cancer grow and become resistant to treatments, aiming to find new ways to fight advanced cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11160595 on ClinicalTrials.gov |
What this research studies
Many cancers grow because certain genes are overactive, often due to extra copies of these genes. This project focuses on special circular DNA pieces, called ecDNAs, which carry these extra gene copies outside of the main chromosomes. These ecDNAs can make cancer cells grow faster, become resistant to drugs, and behave more aggressively. By studying how these ecDNAs form and function, we hope to better understand how they contribute to cancer's development and progression.
Who could benefit from this research
Good fit: Patients with advanced cancers that show aggressive growth or drug resistance, potentially linked to these circular DNA changes, could ultimately benefit from future treatments developed from this research.
Not a fit: Patients whose cancers do not involve these specific circular DNA mechanisms may not directly benefit from treatments based on this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for treating advanced cancers by targeting these circular DNA pieces.
How similar studies have performed: While the existence and general role of these circular DNAs in cancer are recognized, this project aims to answer key unanswered questions about their biology and dynamics, building on recent technological advances.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VENTURA, ANDREA — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: VENTURA, ANDREA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Advanced Cancer, Cancer Genes, Cancer cell line, Cancer-Promoting Gene