Understanding chronic pain through human tissue analysis
Harvard PRECISION Human Pain Center
This study is looking at different types of pain-sensing cells in people with chronic pain to find better treatments, and it's designed for anyone who suffers from ongoing pain and wants to see improvements in how it's managed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10928096 on NIH RePORTER |
What this research studies
This research focuses on chronic pain, which affects over 25 million Americans annually. It aims to improve treatment options by using advanced single-cell technologies to analyze human nociceptor subtypes and their gene expression patterns in various populations and chronic pain conditions. By studying human tissues directly, the research seeks to overcome the limitations of animal models and enhance the translation of findings into effective clinical therapies. The project will also generate valuable data for the scientific community to further advance pain research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic pain conditions, particularly those with phantom limb pain or related issues.
Not a fit: Patients with acute pain or those not experiencing chronic pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic pain, significantly improving patients' quality of life.
How similar studies have performed: Other research has shown promise in using single-cell genomics for understanding pain mechanisms, indicating that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Renthal, William Russell — Brigham and Women's Hospital
- Study coordinator: Renthal, William Russell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.