Understanding changes in molecular rhythms in brain tissue from individuals with psychiatric disorders
Identification of molecular rhythm changes in postmortem tissue from individuals with psychiatric illness
This study is looking at how sleep patterns and disruptions might affect people with bipolar disorder and major depression by examining brain tissue to find changes that could help us understand these conditions better and improve treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11191540 on NIH RePORTER |
What this research studies
This research investigates how circadian rhythms and sleep disruptions affect individuals with psychiatric disorders such as bipolar disorder and major depression. By analyzing postmortem brain tissue, the study aims to identify specific molecular changes that occur in the brains of those with these conditions. The researchers will compare the rhythmic expression of genes in different brain regions to uncover patterns that may be linked to psychiatric symptoms. This approach could provide insights into the biological underpinnings of these disorders and inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with bipolar disorder, major depression, or schizophrenia.
Not a fit: Patients with psychiatric disorders who are not willing to participate in postmortem tissue analysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting circadian rhythms to improve mental health outcomes for patients with psychiatric disorders.
How similar studies have performed: Previous studies have shown that analyzing molecular rhythms in postmortem brain tissue can reveal significant insights into psychiatric disorders, indicating a promising avenue for this research.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Mcclung, Colleen a — University of Pittsburgh at Pittsburgh
- Study coordinator: Mcclung, Colleen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.